[HTML][HTML] Potentiation of Brain-Derived Neurotrophic Factor-Induced Protection of Spiral Ganglion Neurons by C3 Exoenzyme/Rho Inhibitor

J Harre, L Heinkele, M Steffens, A Warnecke… - Frontiers in Cellular …, 2021 - frontiersin.org
… In this study, the effect of different constructs of C3 on SGN alone and … The action of different
constructs of C3 on SGN in vitro have … Despite the lack of a receptor-binding domain, several …

Intrinsic regulation of axon regeneration after spinal cord injury: Recent advances and remaining challenges

HN Noristani - Experimental Neurology, 2022 - Elsevier
… their inhibitory effects on axon regeneration. However, CNS … the DRG lack dendrites
and are pseudo-unipolar with a peripheral … In vivo imaging studies have shown that pre-conditioning …

Anti-glycan antibodies halt axon regeneration in a model of Guillain Barrè Syndrome axonal neuropathy by inducing microtubule disorganization via RhoA–ROCK …

VR Salvador, F Heredia, A Berardo, A Palandri… - Experimental …, 2016 - Elsevier
… permeable version of exoenzyme C3 transferase, TAT-C3, a … Treatment with RhoA and ROCK
inhibitors has no effect on actin … In order to study the effect of C3 or Y-27632 in vitro, DRGn …

Axon regeneration in the central nervous system: facing the challenges from the inside

M Curcio, F Bradke - Annual review of cell and developmental …, 2018 - annualreviews.org
C3 exoenzyme induces axon regeneration after both optic … inhibition with rapamycin has no
effect on axon elongation, … branched axons and in vivo regenerate better following peripheral

Cell Entry of C3 Exoenzyme from Clostridium botulinum

A Rohrbeck, I Just - Uptake and Trafficking of Protein Toxins, 2017 - Springer
C3 exoenzyme has no translocation domain, compared to … fragments were at the cell
periphery and also at the cell … about uptake and molecular effects of C3. However, recently, it …

AAV-mediated transfer of RhoA shRNA and CNTF promotes retinal ganglion cell survival and axon regeneration

LP Cen, JJ Liang, J Chen, AR Harvey, TK Ng, M Zhang… - Neuroscience, 2017 - Elsevier
… could increase axon regeneration in a peripheral nerve (PN)-… in vitro, it had only a very
limited effect on axon regeneration … side effects that may occur when applying, for example, C3

[HTML][HTML] Inhibition of RhoA-subfamily GTPases suppresses Schwann cell proliferation through regulating AKT pathway rather than ROCK pathway

D Tan, J Wen, L Li, X Wang, C Qian, M Pan… - Frontiers in cellular …, 2018 - frontiersin.org
… inhibitor of ROCK, has no significant impact on the parameters of SC … peripheral nerves
and C3 transferase is widely used to promote axonal regeneration in the injured peripheral nerve

[HTML][HTML] Emerging role of extracellular vesicles and exogenous stimuli in molecular mechanisms of peripheral nerve regeneration

Y Izhiman, L Esfandiari - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
… application of Clostridium botulinum C3 exoenzyme (C3), a … and promotes axonal regeneration
both in vivo and in vitro, … Despite these findings, there remains a lack of understanding …

Mechanisms of axon growth and regeneration: moving between development and disease

F Bradke - Journal of Neuroscience, 2022 - Soc Neuroscience
… Live in vivo imaging further showed that on taxol treatment in … effect: the classical paradigm
of axon regeneration elicited by … in neurodegenerative diseases that lack a defined time 0? …

[HTML][HTML] Use of gene therapy in retinal ganglion cell neuroprotection: current concepts and future directions

J Rhee, KC Shih - Biomolecules, 2021 - mdpi.com
… promising results in both in vivo and in vitro models, there is … Exoenzyme C3 transferase
(C3) can inactivate Rho GTPases… , the lack of nucleus entry and therefore the lack of insertional …