[HTML][HTML] Potentiation of Brain-Derived Neurotrophic Factor-Induced Protection of Spiral Ganglion Neurons by C3 Exoenzyme/Rho Inhibitor
J Harre, L Heinkele, M Steffens, A Warnecke… - Frontiers in Cellular …, 2021 - frontiersin.org
… In this study, the effect of different constructs of C3 on SGN alone and … The action of different
constructs of C3 on SGN in vitro have … Despite the lack of a receptor-binding domain, several …
constructs of C3 on SGN in vitro have … Despite the lack of a receptor-binding domain, several …
Intrinsic regulation of axon regeneration after spinal cord injury: Recent advances and remaining challenges
HN Noristani - Experimental Neurology, 2022 - Elsevier
… their inhibitory effects on axon regeneration. However, CNS … the DRG lack dendrites
and are pseudo-unipolar with a peripheral … In vivo imaging studies have shown that pre-conditioning …
and are pseudo-unipolar with a peripheral … In vivo imaging studies have shown that pre-conditioning …
Anti-glycan antibodies halt axon regeneration in a model of Guillain Barrè Syndrome axonal neuropathy by inducing microtubule disorganization via RhoA–ROCK …
VR Salvador, F Heredia, A Berardo, A Palandri… - Experimental …, 2016 - Elsevier
… permeable version of exoenzyme C3 transferase, TAT-C3, a … Treatment with RhoA and ROCK
inhibitors has no effect on actin … In order to study the effect of C3 or Y-27632 in vitro, DRGn …
inhibitors has no effect on actin … In order to study the effect of C3 or Y-27632 in vitro, DRGn …
Axon regeneration in the central nervous system: facing the challenges from the inside
M Curcio, F Bradke - Annual review of cell and developmental …, 2018 - annualreviews.org
… C3 exoenzyme induces axon regeneration after both optic … inhibition with rapamycin has no
effect on axon elongation, … branched axons and in vivo regenerate better following peripheral …
effect on axon elongation, … branched axons and in vivo regenerate better following peripheral …
Cell Entry of C3 Exoenzyme from Clostridium botulinum
A Rohrbeck, I Just - Uptake and Trafficking of Protein Toxins, 2017 - Springer
… C3 exoenzyme has no translocation domain, compared to … fragments were at the cell
periphery and also at the cell … about uptake and molecular effects of C3. However, recently, it …
periphery and also at the cell … about uptake and molecular effects of C3. However, recently, it …
AAV-mediated transfer of RhoA shRNA and CNTF promotes retinal ganglion cell survival and axon regeneration
… could increase axon regeneration in a peripheral nerve (PN)-… in vitro, it had only a very
limited effect on axon regeneration … side effects that may occur when applying, for example, C3 …
limited effect on axon regeneration … side effects that may occur when applying, for example, C3 …
[HTML][HTML] Inhibition of RhoA-subfamily GTPases suppresses Schwann cell proliferation through regulating AKT pathway rather than ROCK pathway
D Tan, J Wen, L Li, X Wang, C Qian, M Pan… - Frontiers in cellular …, 2018 - frontiersin.org
… inhibitor of ROCK, has no significant impact on the parameters of SC … peripheral nerves
and C3 transferase is widely used to promote axonal regeneration in the injured peripheral nerve…
and C3 transferase is widely used to promote axonal regeneration in the injured peripheral nerve…
[HTML][HTML] Emerging role of extracellular vesicles and exogenous stimuli in molecular mechanisms of peripheral nerve regeneration
Y Izhiman, L Esfandiari - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
… application of Clostridium botulinum C3 exoenzyme (C3), a … and promotes axonal regeneration
both in vivo and in vitro, … Despite these findings, there remains a lack of understanding …
both in vivo and in vitro, … Despite these findings, there remains a lack of understanding …
Mechanisms of axon growth and regeneration: moving between development and disease
F Bradke - Journal of Neuroscience, 2022 - Soc Neuroscience
… Live in vivo imaging further showed that on taxol treatment in … effect: the classical paradigm
of axon regeneration elicited by … in neurodegenerative diseases that lack a defined time 0? …
of axon regeneration elicited by … in neurodegenerative diseases that lack a defined time 0? …
[HTML][HTML] Use of gene therapy in retinal ganglion cell neuroprotection: current concepts and future directions
J Rhee, KC Shih - Biomolecules, 2021 - mdpi.com
… promising results in both in vivo and in vitro models, there is … Exoenzyme C3 transferase
(C3) can inactivate Rho GTPases… , the lack of nucleus entry and therefore the lack of insertional …
(C3) can inactivate Rho GTPases… , the lack of nucleus entry and therefore the lack of insertional …